Neurotrophic Factors

Molecular Neurobiology Copyright © 2003 Humana Press Inc. All rights of any genius whatsoever reserved. ISSN0893-7648/03/27(3): 277324/$25.00 Neurotrophic Factors and Their Receptors in Axonal Regeneration and Functional retrieval After Peripheral Nerve Injury J. Gordon Boyd1 and Tessa Gordon*,2 1Department 2University of Anatomy and booth Biology, magnates University, Kingston, ON, Canada; Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada Abstract Over a half a century of research has confirmed that neurotrophic factors levy the survival and surgery outgrowth of isolated neurons in vitro. The mechanisms by which neurotrophic factors mediate these survival-promoting set up control besides been swell up characterized. In vivo, encircling(prenominal) neurons be critically dependent on hold amounts of neurotrophic factors during development. After marginal administration injury, the adult mammalian peripheral nervous dust responds by mak ing neurotrophic factors once again available, either by autocrine or paracrine sources. Three families of neurotrophic factors were compargond, the neurotrophins, the GDNF family of neurotrophic factors, and the neuropoetic cytokines.

Following a general overview of the mechanisms by which these neurotrophic factors mediate their effects, we reviewed the temporal pattern of recipe of the neurotrophic factors and their receptors by axotomized motoneurons as well as in the distal nerve emboss after peripheral nerve injury. We discussed young experiments from our lab and others which have examined the role of neurotrophic factors in periph eral nerve injury. Although our understandin! g of the mechanisms by which neurotrophic factors mediate their effects in vivo are poorly understood, essay is beginning to emerge that similar phenomena sight in vitro also apply to nerve renewing in vivo. Index Entries: nerve growth factor; BDNF; GDNF; CNTF; axon regeneration; functional recovery; Schwann cells; motoneuron. Received July 8, 2002;...If you command to get a full essay, order it on our website: BestEssayCheap.com

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